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PLCG1 a calcium dependent phosphatidylinositol-specific phospholipase C. The activated enzyme produces the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylated and activated by tyrosine kinases in response to signaling through a variety of growth factor receptors and immune system receptors. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC; Motility/polarity/chemotaxis; Phospholipase
Chromosomal Location of Human Ortholog: 2 H2|2 80.97 cM
Cellular Component: cell projection; cytoplasm; cytosol; intercellular junction; lamellipodium; neuron projection; plasma membrane; ruffle; signalosome
Molecular Function: glutamate receptor binding; insulin receptor binding; neurotrophin TRKA receptor binding; phosphoinositide phospholipase C activity; phosphoprotein binding; protein binding; protein kinase binding; receptor tyrosine kinase binding
Biological Process: calcium ion transport; calcium-mediated signaling; cell migration; epidermal growth factor receptor signaling pathway; in utero embryonic development; inositol trisphosphate biosynthetic process; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of release of sequestered calcium ion into cytosol; protein secretion; T cell receptor signaling pathway
Reference #:  Q62077 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1; AI894140; Cded; cell differentiation and embryonic development; OTTMUSP00000001135; Phosphoinositide phospholipase C-gamma-1; phospholipase C, gamma 1; Phospholipase C-gamma-1; Plc-1; PLC-gamma-1; Plc-gamma1; Plcg-1; Plcg1
Gene Symbols: Plcg1
Molecular weight: 149,668 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Angiogenesis  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  Phospholipase Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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