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PLD1 a phosphatidylcholine-hydrolyzing phospholipase. Activated by ADP-ribosylated Rho and protein kinase C. Implicated as a critical step in numerous cellular pathways including membrane trafficking and the regulation polymorphonuclear leukocyte degranulation and oxidant production. May be involved in the regulation of perinuclear intravesicular membrane traffic. Four splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase
Chromosomal Location of Human Ortholog: 3q26.31
Cellular Component: apical plasma membrane; endocytic vesicle; endoplasmic reticulum membrane; endosome; Golgi apparatus; lysosomal membrane; membrane; plasma membrane
Molecular Function: phospholipase D activity; protein binding
Biological Process: cell motility involved in cell locomotion; chemotaxis; neutrophil degranulation; phosphatidic acid biosynthetic process; Ras protein signal transduction; regulation of microvillus biogenesis; small GTPase mediated signal transduction
Reference #:  Q13393 (UniProtKB)
Alt. Names/Synonyms: Choline phosphatase 1; hPLD1; Phosphatidylcholine-hydrolyzing phospholipase D1; Phospholipase D1; phospholipase D1, phophatidylcholine-specific; phospholipase D1, phosphatidylcholine-specific; PLD 1; PLD1
Gene Symbols: PLD1
Molecular weight: 124,184 Da
Basal Isoelectric point: 8.91  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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