a phosphatidylcholine-hydrolyzing phospholipase. Activated by ADP-ribosylated Rho and protein kinase C. Implicated as a critical step in numerous cellular pathways including membrane trafficking and the regulation polymorphonuclear leukocyte degranulation and oxidant production. May be involved in the regulation of perinuclear intravesicular membrane traffic. Four splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Molecular Function: phospholipase D activity; protein binding
Biological Process: cell motility involved in cell locomotion; chemotaxis; neutrophil degranulation; phosphatidic acid biosynthetic process; Ras protein signal transduction; regulation of microvillus biogenesis; small GTPase mediated signal transduction