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ADRB1 a GPCR-coupled 7 transmembrane receptor that binds epinephrine and norepinephrine with approximately equal affinity. Mediates the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Interacts with PIST and PSD-95. Localized at the plasma membrane and in the Golgi upon PIST overexpression. Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 10q25.3
Cellular Component: early endosome; integral to plasma membrane; plasma membrane
Molecular Function: alpha-2A adrenergic receptor binding; beta-adrenergic receptor activity; beta1-adrenergic receptor activity; epinephrine binding; norepinephrine binding; PDZ domain binding; protein binding; protein heterodimerization activity; Ras guanyl-nucleotide exchange factor activity; receptor signaling protein activity
Biological Process: adenylate cyclase activation; cell-cell signaling; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure; positive regulation of cAMP biosynthetic process; positive regulation of GTPase activity; positive regulation of heart rate by epinephrine-norepinephrine; thermoregulation
Disease: Resting Heart Rate, Variation In
Reference #:  P08588 (UniProtKB)
Alt. Names/Synonyms: ADRB1; ADRB1R; adrenergic, beta-1-, receptor; B1AR; Beta-1 adrenergic receptor; Beta-1 adrenoceptor; Beta-1 adrenoreceptor; BETA1AR; RHR
Gene Symbols: ADRB1
Molecular weight: 51,323 Da
Basal Isoelectric point: 9.23  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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