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GNL3 May be required to maintain the proliferative capacity of stem cells and may play an important role in tumorigenesis. May interact with p53/TP53 via its basic domain. Increased levels in lung tissue in cancer patients. Belongs to the MMR1/HSR1 GTP-binding protein family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Hydrolase; Nucleolus; RNA-binding
Chromosomal Location of Human Ortholog: 3p21.1
Cellular Component: extracellular space; membrane; nuclear body; nucleolus; nucleus
Molecular Function: GTP binding; GTPase activity; mRNA 5'-UTR binding; protein binding; RNA binding
Biological Process: positive regulation of protein sumoylation; positive regulation of telomere maintenance; regulation of cell proliferation; ribosome biogenesis and assembly; stem cell division; stem cell maintenance
Reference #:  Q9BVP2 (UniProtKB)
Alt. Names/Synonyms: C77032; E2-induced gene 3 protein; E2IG3; estradiol-induced nucleotide binding protein; GNL3; guanine nucleotide binding protein-like 3 (nucleolar); Guanine nucleotide-binding protein-like 3; MGC800; NNP47; Novel nucleolar protein 47; NS; Nucleolar GTP-binding protein 3; Nucleostemin
Gene Symbols: GNL3
Molecular weight: 61,993 Da
Basal Isoelectric point: 9.23  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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