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HMGA2 Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Interacts with E4F1. Interacts with NEK2. Belongs to the HMGA family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Oncoprotein
Chromosomal Location of Human Ortholog: 12q14.3
Cellular Component: nuclear chromosome; nucleoplasm; nucleus
Molecular Function: 5'-deoxyribose-5-phosphate lyase activity; AT DNA binding; DNA bending activity; DNA-(apurinic or apyrimidinic site) lyase activity; DNA-dependent protein kinase activity; nucleosomal DNA binding; protein binding; SMAD binding; transcription factor binding
Biological Process: base-excision repair; chondrocyte differentiation; chromosome breakage; DNA damage response, detection of DNA damage; epithelial to mesenchymal transition; establishment and/or maintenance of chromatin architecture; fat cell differentiation; heterochromatin formation; mesenchymal cell differentiation; mesodermal cell differentiation; mitotic cell cycle G2/M transition DNA damage checkpoint; multicellular organismal development; negative regulation of apoptosis; negative regulation of DNA binding; negative regulation of retroviral genome replication; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of apoptosis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; response to virus; stem cell differentiation
Disease: Leiomyoma, Uterine
Reference #:  P52926 (UniProtKB)
Alt. Names/Synonyms: BABL; high mobility group AT-hook 2; High mobility group AT-hook protein 2; High mobility group protein HMGI-C; high-mobility group (nonhistone chromosomal) protein isoform I-C; High-mobility group protein HMGI-C; HMGA2; HMGI-C; HMGIC; LIPO; STQTL9
Gene Symbols: HMGA2
Molecular weight: 11,832 Da
Basal Isoelectric point: 10.63  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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