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CLIC4 Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical- basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Belongs to the chloride channel CLIC family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p36.11
Cellular Component: actin cytoskeleton; apical part of cell; cell surface; centrosome; cytoplasm; cytosol; intercellular junction; intracellular; microtubule cytoskeleton; microvillus; midbody; mitochondrion; nuclear matrix; perinuclear region of cytoplasm; plasma membrane
Molecular Function: chloride channel activity; glutathione transferase activity; protein binding
Biological Process: angiogenesis; cell differentiation; glutathione metabolic process; keratinocyte differentiation; negative regulation of cell migration
Reference #:  Q9Y696 (UniProtKB)
Alt. Names/Synonyms: chloride intracellular channel 4; chloride intracellular channel 4 like; Chloride intracellular channel protein 4; CLIC4; CLIC4L; DKFZp566G223; FLJ38640; H1; huH1; Intracellular chloride ion channel protein p64H1; MTCLIC; p64H1
Gene Symbols: CLIC4
Molecular weight: 28,772 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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