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GCN2 a kinase of the PEK family. Phosphorylates and inhibits eukaryotic initiation factor (eIF)-2 alpha, providing an important protective mechanism during various cellular stress conditions including endoplasmic reticulum (ER) stress. Note: This description may include information from UniProtKB.
Protein type: EC; GCN2 subfamily; Kinase, protein; Other group; PEK family; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation
Chromosomal Location of Human Ortholog: 15q15.1
Cellular Component: polysome
Molecular Function: eukaryotic translation initiation factor 2alpha kinase activity; protein serine/threonine kinase activity; tRNA binding
Biological Process: cellular response to amino acid starvation; inhibition of CREB transcription factor; learning; long-term memory; negative regulation of neuron differentiation; negative regulation of translation initiation in response to stress; negative regulation of translational initiation; positive regulation of adaptive immune response; positive regulation of defense response to virus by host; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of translational initiation; T cell activation during immune response; viral protein biosynthetic process
Disease: Pulmonary Venoocclusive Disease 2, Autosomal Recessive
Reference #:  Q9P2K8 (UniProtKB)
Alt. Names/Synonyms: E2AK4; EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4; Eukaryotic translation initiation factor 2-alpha kinase 4; GCN2; GCN2 eIF2alpha kinase; GCN2-like protein; KIAA1338
Gene Symbols: EIF2AK4
Molecular weight: 186,911 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF2
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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