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DROSHA a nuclear type-III RNase that, along with the DGCR8, executes the initial step of microRNA (miRNA) processing in the nucleus. Cleaves the local hairpin structures embedded in long primary microRNA transcripts (pri-miRNAs) into pre-miRNAs. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Interacts with Sp1. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Nucleolus; RNA processing; RNA-binding; Ribonuclease
Chromosomal Location of Human Ortholog: 5p13.3
Cellular Component: focal adhesion; nucleoplasm; nucleus; plasma membrane
Molecular Function: DEAD/H-box RNA helicase binding; double-stranded RNA binding; lipopolysaccharide binding; protein binding; protein homodimerization activity; ribonuclease III activity; RNA binding; SMAD binding
Biological Process: defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; pre-microRNA processing; primary microRNA processing; RNA interference, production of siRNA
Reference #:  Q9NRR4 (UniProtKB)
Alt. Names/Synonyms: Drosha; drosha, double-stranded RNA-specific endoribonuclease; drosha, ribonuclease type III; ETOHI2; HSA242976; nuclear RNase III Drosha; p241; putative protein p241 which interacts with transcription factor Sp1; putative ribonuclease III; RANSE3L; Ribonuclease 3; Ribonuclease III; ribonuclease III, nuclear; ribonuclease type III, nuclear; RN3; RNase III; RNASE3L; RNASEN; RNC
Gene Symbols: DROSHA
Molecular weight: 159,316 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.
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