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RGS4 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and visual cortex. Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not expressed in the cerebellum. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, RGS
Chromosomal Location of Human Ortholog: 1q23.3
Cellular Component: cytoplasm; nucleus; plasma membrane
Molecular Function: calmodulin binding; GTPase activator activity
Biological Process: inactivation of MAPK activity; regulation of G-protein coupled receptor protein signaling pathway
Disease: Schizophrenia 9
Reference #:  P49798 (UniProtKB)
Alt. Names/Synonyms: DKFZp761F1924; MGC2124; MGC60244; Regulator of G-protein signaling 4; regulator of G-protein signalling 4; RGP4; RGS4; schizophrenia disorder 9; SCZD9
Gene Symbols: RGS4
Molecular weight: 23,256 Da
Basal Isoelectric point: 8.69  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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