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LEF-1 a transcription factor of the TCF/LEF family. Participates in the Wnt signaling pathway and regulates T-cell receptor alpha-C enhancer function. Activates transcription of target genes in the presence of CTNNB1 and EP300. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1. Deletions in LEF1 have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Four human isoforms produced by alternative promoter usage and alternative splicing have been described. Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 4q25
Cellular Component: cytoplasm; nucleoplasm; nucleus; transcription factor complex
Molecular Function: beta-catenin binding; caspase inhibitor activity; DNA bending activity; DNA binding; estrogen receptor activity; estrogen receptor binding; gamma-catenin binding; histone binding; histone deacetylase binding; protein binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription factor activity
Biological Process: alpha-beta T cell differentiation; B cell proliferation; BMP signaling pathway; dentate gyrus development; embryonic limb morphogenesis; epithelial to mesenchymal transition; eye pigmentation; forebrain neuroblast division; forebrain neuron differentiation; formation of radial glial scaffolds; hypothalamus development; mammary gland development; muscle fiber development; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of DNA binding; negative regulation of interleukin-13 production; negative regulation of interleukin-4 production; negative regulation of interleukin-5 production; negative regulation of transcription, DNA-dependent; neural crest cell migration; neutrophil differentiation; osteoblast differentiation; palate development; paraxial mesoderm formation; patterning of blood vessels; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of granulocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; radial glial cell differentiation in the forebrain; regulation of cell-cell adhesion; regulation of striated muscle development; somitogenesis; sprouting angiogenesis; T-helper 1 cell differentiation; transcription from RNA polymerase II promoter; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, calcium modulating pathway
Reference #:  Q9UJU2 (UniProtKB)
Alt. Names/Synonyms: DKFZp586H0919; FLJ46390; LEF-1; LEF1; Lymphoid enhancer-binding factor 1; T cell-specific transcription factor 1-alpha; TCF1-alpha; TCF1ALPHA
Gene Symbols: LEF1
Molecular weight: 44,201 Da
Basal Isoelectric point: 6.9  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
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