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UBE1L2 Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin- E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. Belongs to the ubiquitin-activating E1 family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 4q13.2
Cellular Component: cytoplasm; cytosol
Molecular Function: FAT10 activating enzyme activity; protein binding; ubiquitin activating enzyme activity
Biological Process: protein ubiquitination; response to DNA damage stimulus; ubiquitin-dependent protein catabolic process
Reference #:  A0AVT1 (UniProtKB)
Alt. Names/Synonyms: FLJ10808; FLJ23367; Monocyte protein 4; MOP-4; MOP4; UBA6; UBA6, ubiquitin-activating enzyme E1; UBE1L2; Ubiquitin-activating enzyme 6; ubiquitin-activating enzyme E1-like 2; Ubiquitin-activating enzyme E1-like protein 2; ubiquitin-like modifier activating enzyme 6; Ubiquitin-like modifier-activating enzyme 6
Gene Symbols: UBA6
Molecular weight: 117,970 Da
Basal Isoelectric point: 5.76  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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