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STING Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti- viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Associates with the MHC-II complex. Homodimer; 'Lys-63'-linked ubiquitination at Lys-150 is required for homodimerization. Interacts with DDX58/RIG-I, MAVS/VISA and SSR2. Interacts with RNF5 and TRIM56. Interacts with TBK1; when homodimer, leading to subsequent production of IFN-beta. Ubiquitously expressed. Belongs to the TMEM173 family. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial
Chromosomal Location of Human Ortholog: 5q31.2
Cellular Component: cytoplasmic vesicle membrane; cytosol; endoplasmic reticulum membrane; mitochondrial outer membrane; nucleoplasm; perinuclear region of cytoplasm; plasma membrane; secretory granule membrane
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protein kinase binding; transcription factor binding
Biological Process: activation of innate immune response; defense response to virus; innate immune response; interferon-beta production; neutrophil degranulation; positive regulation of defense response to virus by host; positive regulation of interferon type I production; positive regulation of protein binding; positive regulation of protein import into nucleus, translocation; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; regulation of interferon type I production
Disease: Sting-associated Vasculopathy, Infantile-onset
Reference #:  Q86WV6 (UniProtKB)
Alt. Names/Synonyms: endoplasmic reticulum IFN stimulator; ERIS; FLJ38577; hMITA; hSTING; Mediator of IRF3 activation; MITA; mitochondrial mediator of IRF3 activation; MPYS; N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner; NET23; Stimulator of interferon genes protein; STING; TM173; TMEM173; Transmembrane protein 173
Gene Symbols: TMEM173
Molecular weight: 42,193 Da
Basal Isoelectric point: 6.6  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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