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5-HT(1A) This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family. 5- hydroxytryptamine receptor subfamily. HTR1A sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 5q12.3
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: neurotransmitter receptor activity; protein binding; serotonin binding; serotonin receptor activity
Biological Process: behavioral fear response; G-protein coupled receptor protein signaling pathway; positive regulation of cell proliferation; regulation of dopamine metabolic process; regulation of serotonin secretion; serotonin metabolic process; serotonin receptor signaling pathway; serotonin receptor, adenylate cyclase inhibiting pathway
Disease: Periodic Fever, Menstrual Cycle-dependent
Reference #:  P08908 (UniProtKB)
Alt. Names/Synonyms: 5-HT-1A; 5-HT1A; 5-HT1a receptor; 5-hydroxytryptamine (serotonin) receptor 1A; 5-hydroxytryptamine receptor 1A; 5HT1a; ADRB2RL1; ADRBRL1; G protein coupled receptor; G-21; guanine nucleotide-binding regulatory protein-coupled receptor; HTR1A; Serotonin receptor 1A
Gene Symbols: HTR1A
Molecular weight: 46,107 Da
Basal Isoelectric point: 9.13  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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