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SIRT3 a soluble mitochondrial NAD-dependent protein deacetylase. Can deacetylate and thereby activate a central metabolic regulator in the mitochondrial matrix, glutamate dehydrogenase. Mitochondrial proteins are hyperacetylated in SIRT3-deficient mice, but not in SIRT4 or SIRT5 deficient mice. SIRT3-deficient mice have no obvious metabolic phenotype, and the process of adaptive thermogenesis is normal. Can deacetylate and activate isocitrate dehydrogenase 2, an enzyme that participates in regulation of the citric acid cycle and the regeneration of antioxidants. Inhibited by nicotinamide, but not by trichostatin A. Its unprocessed form is enzymatically inactive. It is processed by mitochondrial processing peptidase (MPP) in the mitochondrial matrix to give an enzymatically active 28 kDa product. Note: This description may include information from UniProtKB.
Protein type: Deacetylase; EC 3.5.1.-; Mitochondrial
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: mitochondrial matrix; mitochondrion
Molecular Function: NAD+ ADP-ribosyltransferase activity; protein binding; zinc ion binding
Biological Process: aerobic respiration; mitochondrion organization and biogenesis; protein amino acid ADP-ribosylation; protein amino acid deacetylation
Reference #:  Q9NTG7 (UniProtKB)
Alt. Names/Synonyms: hSIRT3; mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase; NAD-dependent deacetylase sirtuin-3, mitochondrial; silent mating type information regulation 2, S.cerevisiae, homolog 3; sir2-like 3; SIR2-like protein 3; SIR2L3; SIRT3; sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae); sirtuin type 3
Gene Symbols: SIRT3
Molecular weight: 43,573 Da
Basal Isoelectric point: 8.98  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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