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ORC6L Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. ORC is composed of six subunits. In human, ORC is cell cycle-dependent regulated: it is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4. Belongs to the ORC6 family. Note: This description may include information from UniProtKB.
Protein type: DNA replication
Chromosomal Location of Human Ortholog: 16q11.2
Cellular Component: fibrillar center; membrane; nuclear origin of replication recognition complex; nucleoplasm; nucleus; origin recognition complex
Molecular Function: DNA replication origin binding; protein binding
Biological Process: DNA replication; DNA replication initiation; G1/S transition of mitotic cell cycle; negative regulation of cell division
Disease: Meier-gorlin Syndrome 3
Reference #:  Q9Y5N6 (UniProtKB)
Alt. Names/Synonyms: ORC6; ORC6L; Origin recognition complex subunit 6; origin recognition complex, subunit 6 homolog-like; origin recognition complex, subunit 6 like (yeast)
Gene Symbols: ORC6
Molecular weight: 28,107 Da
Basal Isoelectric point: 8.91  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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