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NR2F1 Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG. Binds DNA as dimer; homodimer and probable heterodimer with NR2F6. Interacts with COPS2. Inhibited by gonadotropin in granulosa cells. Belongs to the nuclear hormone receptor family. NR2 subfamily. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor; Transcription factor
Chromosomal Location of Human Ortholog: 5q15
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor activity
Biological Process: negative regulation of transcription from RNA polymerase II promoter; signal transduction; transcription initiation from RNA polymerase II promoter
Disease: Bosch-boonstra-schaaf Optic Atrophy Syndrome
Reference #:  P10589 (UniProtKB)
Alt. Names/Synonyms: COT1; COUP transcription factor 1; COUP transcription factor I; COUP-TF I; COUP-TF1; COUP-TFI; EAR-3; EAR3; ERBAL3; NR2F1; NR2F2; Nuclear receptor subfamily 2 group F member 1; nuclear receptor subfamily 2, group F, member 1; SVP44; TCFCOUP1; TFCOUP1; transcription factor COUP 1 (chicken ovalbumin upstream promoter 1, v-erb-a homolog-like 3); V-erbA-related protein 3
Gene Symbols: NR2F1
Molecular weight: 46,156 Da
Basal Isoelectric point: 8.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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