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PAX3 Probable transcription factor associated with development of alveolar rhabdomyosarcoma. Can bind to DNA as a heterodimer with PAX7. Interacts with DAXX. Belongs to the paired homeobox family. 7 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 2q36.1
Cellular Component: nucleoplasm
Molecular Function: protein binding; sequence-specific DNA binding
Biological Process: apoptosis; organ morphogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; sensory perception of sound; transcription from RNA polymerase II promoter
Disease: Craniofacial-deafness-hand Syndrome; Rhabdomyosarcoma 2; Waardenburg Syndrome, Type 1; Waardenburg Syndrome, Type 3
Reference #:  P23760 (UniProtKB)
Alt. Names/Synonyms: CDHS; HUP2; MGC120381; MGC120382; MGC120383; MGC120384; MGC134778; paired box 3; paired box homeotic gene 3; Paired box protein Pax-3; paired domain gene 3; paired domain gene HuP2; PAX3; WS1; WS3
Gene Symbols: PAX3
Molecular weight: 52,968 Da
Basal Isoelectric point: 8.92  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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