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ACSL1 Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate. Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas. Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Ligase; Lipid Metabolism - fatty acid; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q35.1
Cellular Component: endoplasmic reticulum membrane; membrane; mitochondrial outer membrane; mitochondrion
Molecular Function: long-chain-fatty-acid-CoA ligase activity
Biological Process: linoleic acid metabolic process; lipid biosynthetic process; long-chain fatty acid metabolic process; regulation of lipid metabolic process
Reference #:  P33121 (UniProtKB)
Alt. Names/Synonyms: ACS1; ACSL1; Acyl-CoA synthetase 1; acyl-CoA synthetase long-chain family member 1; FACL1; FACL2; fatty-acid-Coenzyme A ligase, long-chain 1; fatty-acid-Coenzyme A ligase, long-chain 2; LACS; LACS 1; LACS 2; LACS1; LACS2; lignoceroyl-CoA synthase; Long-chain acyl-CoA synthetase 1; Long-chain acyl-CoA synthetase 2; Long-chain fatty acid-CoA ligase 2; long-chain fatty-acid-coenzyme A ligase 1; Long-chain-fatty-acid--CoA ligase 1; Palmitoyl-CoA ligase 1; Palmitoyl-CoA ligase 2; paltimoyl-CoA ligase 1
Gene Symbols: ACSL1
Molecular weight: 77,943 Da
Basal Isoelectric point: 6.81  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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