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DAGLBETA Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses. Belongs to the AB hydrolase superfamily. Lipase family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.1.-; Lipase; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 7p22.1
Cellular Component: lysosomal membrane; nucleus; plasma membrane
Molecular Function: acylglycerol lipase activity
Biological Process: arachidonic acid metabolic process
Reference #:  Q8NCG7 (UniProtKB)
Alt. Names/Synonyms: DAGLB; DAGLBETA; DGL-beta; DGLB; diacylglycerol lipase, beta; FLJ33624; FLJ33909; FLJ45532; KCCR13L; Sn1-specific diacylglycerol lipase beta
Gene Symbols: DAGLB
Molecular weight: 73,732 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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