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Bcl-10 a ubiquitous pro-apoptotic protein that promotes pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Self-associates via CARD-CARD interactions; forms a tight complex with MALT1. Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2. Defects in BCL10 are involved in various types of cancer. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor
Chromosomal Location of Human Ortholog: 1p22.3
Cellular Component: cytoplasm; cytoplasmic microtubule; cytosol; lipopolysaccharide receptor complex; lysosome; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex; T cell receptor complex
Molecular Function: enzyme binding; identical protein binding; kinase activator activity; kinase binding; NF-kappaB binding; protease binding; protein binding; protein C-terminus binding; protein kinase B binding; protein kinase binding; protein self-association; transcription coactivator activity; transcription factor binding; ubiquitin binding; ubiquitin protein ligase binding
Biological Process: activation of NF-kappaB transcription factor; adaptive immune response; cell death; innate immune response; negative regulation of mature B cell apoptosis; neural tube closure; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-8 biosynthetic process; positive regulation of phosphorylation; positive regulation of protein ubiquitination; positive regulation of transcription, DNA-dependent; protein homooligomerization; protein oligomerization; protein ubiquitination; response to food; response to molecule of bacterial origin; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; toll-like receptor signaling pathway
Disease: Follicular Lymphoma, Susceptibility To, 1; Gastric Lymphoma, Primary; Immunodeficiency 37; Lymphoma, Non-hodgkin, Familial; Mesothelioma, Malignant; Testicular Germ Cell Tumor
Reference #:  O95999 (UniProtKB)
Alt. Names/Synonyms: B-cell CLL/lymphoma 10; B-cell lymphoma/leukemia 10; Bcl-10; BCL10; c-E10; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; CARD-containing molecule enhancing NF-kappa-B; CARD-containing proapoptotic protein; CARD-like apoptotic protein; CARMEN; caspase-recruiting domain-containing protein; cCARMEN; CED-3/ICH-1 prodomain homologous E10-like regulator; Cellular homolog of vCARMEN; Cellular-E10; CIPER; CLAP; hCLAP; Mammalian CARD-containing adapter molecule E10; mE10
Gene Symbols: BCL10
Molecular weight: 26,252 Da
Basal Isoelectric point: 5.57  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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