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K4 Heterotetramer of two type I and two type II keratins. Keratin-4 is generally associated with keratin-13. Detected in the suprabasal layer of the stratified epithelium of the esophagus, exocervix, vagina, mouth and lingual mucosa, and in cells and cell clusters in the mucosa and serous gland ducts of the esophageal submucosa. Expressed widely in the exocervix and esophageal epithelium, with lowest levels detected in the basal cell layer. Belongs to the intermediate filament family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component: cell surface; cytosol; intermediate filament cytoskeleton; keratin filament; nucleus
Molecular Function: protein binding
Biological Process: cytoskeleton organization and biogenesis; epithelial cell differentiation; keratinization; negative regulation of epithelial cell proliferation
Disease: White Sponge Nevus 1
Reference #:  P19013 (UniProtKB)
Alt. Names/Synonyms: CK-4; CK4; CYK4; cytokeratin 4; Cytokeratin-4; FLJ31692; K2C4; K4; keratin 4; Keratin, type II cytoskeletal 4; Keratin-4; KRT4; Type-II keratin Kb4
Gene Symbols: KRT4
Molecular weight: 57,285 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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