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ENG Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It is able to bind TGF-beta 1, and 3 efficiently and TGF-beta 2 less efficiently. Interacts with TCTEX1D4. Interacts with ARRB2. Endoglin is restricted to endothelial cells in all tissues except bone marrow. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 9q34.11
Cellular Component: external side of plasma membrane; extracellular space; focal adhesion; receptor complex
Molecular Function: activin binding; galactose binding; glycosaminoglycan binding; protein binding; protein homodimerization activity; transforming growth factor beta binding; transforming growth factor beta receptor, cytoplasmic mediator activity; transmembrane receptor activity; type II transforming growth factor beta receptor binding
Biological Process: artery morphogenesis; atrial cardiac muscle morphogenesis; BMP signaling pathway; branching involved in blood vessel morphogenesis; cell adhesion; central nervous system vasculogenesis; chronological cell aging; heart looping; negative regulation of cell migration; negative regulation of protein autophosphorylation; positive regulation of angiogenesis; positive regulation of BMP signaling pathway; positive regulation of collagen biosynthetic process; positive regulation of protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-templated; regulation of transforming growth factor beta receptor signaling pathway; response to corticosteroid stimulus; response to drug; smooth muscle development; sprouting angiogenesis; vasculogenesis; venous blood vessel morphogenesis
Disease: Telangiectasia, Hereditary Hemorrhagic, Of Rendu, Osler, And Weber
Reference #:  P17813 (UniProtKB)
Alt. Names/Synonyms: CD105; CD105 antigen; EGLN; END; Endoglin; ENG; FLJ41744; HHT1; ORW; ORW1
Gene Symbols: ENG
Molecular weight: 70,578 Da
Basal Isoelectric point: 6.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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