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STAT3 transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Constitutively active in a number of human tumors. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor
Chromosomal Location of Human Ortholog: 11 D|11 63.82 cM
Cellular Component: cytoplasm; cytosol; mitochondrial inner membrane; mitochondrion; nuclear chromatin; nucleoplasm; nucleus; plasma membrane
Molecular Function: CCR5 chemokine receptor binding; chromatin DNA binding; DNA binding; glucocorticoid receptor binding; identical protein binding; ligand-dependent nuclear receptor activity; protein binding; protein dimerization activity; protein homodimerization activity; protein kinase binding; protein phosphatase binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding
Biological Process: astrocyte differentiation; cell proliferation; cellular response to hormone stimulus; eating behavior; eye photoreceptor cell differentiation; glucose homeostasis; inflammatory response; intracellular receptor-mediated signaling pathway; JAK-STAT cascade; leptin-mediated signaling pathway; miRNA-mediated gene silencing, negative regulation of translation; mRNA transcription from RNA polymerase II promoter; negative regulation of apoptosis; negative regulation of cell proliferation; negative regulation of glycolysis; phosphorylation; positive regulation of cell proliferation; positive regulation of erythrocyte differentiation; positive regulation of Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein import into nucleus; radial glial cell differentiation; regulation of cell cycle; regulation of mitochondrial membrane permeability; regulation of multicellular organism growth; regulation of transcription, DNA-dependent; response to cytokine stimulus; response to estradiol stimulus; sexual reproduction; stem cell maintenance; thermoregulation; transcription from RNA polymerase II promoter
Reference #:  P42227 (UniProtKB)
Alt. Names/Synonyms: 1110034C02Rik; acute phase response factor; Acute-phase response factor; Aprf; AW109958; OTTMUSP00000002052; OTTMUSP00000002053; Signal transducer and activator of transcription 3; Stat3
Gene Symbols: Stat3
Molecular weight: 88,054 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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