Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:
CASP7 iso2

CASP7 iso2 Involved in the activation cascade of caspases responsible for apoptosis execution (By similarity). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Loss of zygotic DCP-1 function causes larval lethality and melanotic tumors.
Protein type: Apoptosis; EC; Endoplasmic reticulum; Mitochondrial; Protease
Cellular Component: cytosol; mitochondrion
Molecular Function: cysteine-type endopeptidase activity; protein binding
Biological Process: actin filament organization; apoptosis; autophagic cell death; cellular response to starvation; cytoplasmic transport, nurse cell to oocyte; multicellular organismal development; neuron remodeling; nurse cell apoptosis; oogenesis; ovarian nurse cell to oocyte transport; positive regulation of autophagy; positive regulation of macroautophagy; programmed cell death; salivary gland cell autophagic cell death
Reference #:  O02002 (UniProtKB)
Alt. Names/Synonyms: Caspase-1; Caspase-1 subunit p13; Caspase-1 subunit p22; CG5370; Dcp-1; Dcp1
Gene Symbols: Dcp-1
Molecular weight: 35,927 Da
Basal Isoelectric point: 7.63  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CASP7 iso2

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

Scansite  |  Pfam  |  ENZYME  |  GeneCards  |  UniProtKB  |  Entrez-Gene