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STMN1 a microtubule-associated protein involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Phosphorylation reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, nonleukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 1p36.11
Cellular Component: cytoplasm; intracellular; neuron projection
Molecular Function: protein binding; signal transducer activity; tubulin binding
Biological Process: cytokinesis after mitosis; hepatocyte growth factor receptor signaling pathway; microtubule depolymerization; mitotic spindle organization and biogenesis; negative regulation of microtubule polymerization; negative regulation of Rho protein signal transduction; negative regulation of stress fiber formation; neurite development; regulation of microtubule polymerization or depolymerization; response to virus
Reference #:  P16949 (UniProtKB)
Alt. Names/Synonyms: C1orf215; FLJ32206; Lag; LAP18; Leukemia-associated phosphoprotein p18; Metablastin; MGC138869; MGC138870; Oncoprotein 18; OP18; phosphoprotein 19; Phosphoprotein p19; pp17; pp19; PR22; Prosolin; Protein Pr22; SMN; Stathmin; stathmin 1; stathmin 1/oncoprotein 18; STMN1; transmembrane protein C1orf215
Gene Symbols: STMN1
Molecular weight: 17,303 Da
Basal Isoelectric point: 5.76  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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