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Protein Page:

LIG1 is an enzyme that functions in DNA replication and the base excision repair process. Mutations leading to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; EC; Ligase
Chromosomal Location of Human Ortholog: 7 A1|7 7.82 cM
Cellular Component: intracellular membrane-bound organelle; mitochondrion; nucleoplasm; nucleus
Molecular Function: DNA ligase (ATP) activity; DNA ligase activity
Biological Process: base-excision repair; DNA repair; DNA replication; double-strand break repair via nonhomologous end joining; response to hydrogen peroxide
Reference #:  P37913 (UniProtKB)
Alt. Names/Synonyms: AL033288; DNA ligase 1; DNA ligase I; DNLI1; Lig-1; Lig1; ligase I, DNA, ATP-dependent; LigI; Polydeoxyribonucleotide synthase [ATP] 1
Gene Symbols: Lig1
Molecular weight: 102,290 Da
Basal Isoelectric point: 6.43  Predict pI for various phosphorylation states
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