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OCRL Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5- tetrakisphosphate to inositol 1,3,4-trisphosphate. May function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes. Belongs to the inositol-1,4,5-trisphosphate 5- phosphatase type II family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC; Motility/polarity/chemotaxis; Phosphatase (non-protein)
Chromosomal Location of Human Ortholog: Xq26.1
Cellular Component: clathrin-coated vesicle; cytoplasm; cytosol; early endosome; Golgi stack; Golgi-associated vesicle; nucleus; photoreceptor outer segment; plasma membrane; trans-Golgi network
Molecular Function: GTPase activator activity; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; phosphoinositide 5-phosphatase activity; protein binding; Rac GTPase binding
Biological Process: inositol phosphate metabolic process; phosphatidylinositol biosynthetic process; regulation of GTPase activity; regulation of small GTPase mediated signal transduction
Disease: Dent Disease 2; Lowe Oculocerebrorenal Syndrome
Reference #:  Q01968 (UniProtKB)
Alt. Names/Synonyms: Inositol polyphosphate 5-phosphatase OCRL-1; INPP5F; LOCR; Lowe oculocerebrorenal syndrome protein; NPHL2; OCRL; OCRL1; oculocerebrorenal syndrome of Lowe; phosphatidylinositol polyphosphate 5-phosphatase
Gene Symbols: OCRL
Molecular weight: 104,205 Da
Basal Isoelectric point: 6.13  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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