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PREX1 Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. Interacts preferentially with RAC2. Interacts with RAC1. Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rac/Rho
Chromosomal Location of Human Ortholog: 20q13.13
Cellular Component: cytosol; plasma membrane
Molecular Function: enzyme binding; GTPase activator activity; guanyl-nucleotide exchange factor activity; phospholipid binding; protein binding; Rac guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity
Biological Process: actin filament polymerization; G-protein coupled receptor protein signaling pathway; negative regulation of protein kinase activity; negative regulation of TOR signaling pathway; neutrophil activation; positive regulation of apoptosis; regulation of small GTPase mediated signal transduction; superoxide metabolic process
Reference #:  Q8TCU6 (UniProtKB)
Alt. Names/Synonyms: KIAA1415; P-Rex1; Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1; PREX1; PtdIns(3,4,5)-dependent Rac exchanger 1
Gene Symbols: PREX1
Molecular weight: 186,203 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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