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ATG4C Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Highly expressed in skeletal muscle, heart, liver and testis. Inhibited by N-ethylmaleimide. Belongs to the peptidase C54 family. Note: This description may include information from UniProtKB.
Protein type: Autophagy; EC 3.4.22.-; Protease; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 1p31.3
Cellular Component: cytoplasm; cytosol; extracellular region
Molecular Function: cysteine-type endopeptidase activity; peptidase activity
Biological Process: autophagic vacuole formation; autophagy; C-terminal protein lipidation; mitochondrion degradation; protein delipidation; protein targeting to membrane; proteolysis
Reference #:  Q96DT6 (UniProtKB)
Alt. Names/Synonyms: APG4 autophagy 4 homolog C; APG4-C; APG4C; ATG4 autophagy related 4 homolog C (S. cerevisiae); ATG4C; AUT-like 1, cysteine endopeptidase; AUT-like 3 cysteine endopeptidase; AUTL1; AUTL3; Autophagin-3; Autophagy-related cysteine endopeptidase 3; Autophagy-related protein 4 homolog C; Cysteine protease ATG4C; FLJ14867
Gene Symbols: ATG4C
Molecular weight: 52,497 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
CST Pathways:  Autophagy Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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