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CCND1 a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Note: This description may include information from UniProtKB.
Protein type: Activator; Cell cycle regulation; Nuclear receptor co-regulator; Oncoprotein
Chromosomal Location of Human Ortholog: 7 F5|7 88.92 cM
Cellular Component: cyclin-dependent protein kinase holoenzyme complex; cytoplasm; intracellular; nucleoplasm; nucleus; tight junction; transcriptional repressor complex
Molecular Function: cyclin-dependent protein kinase activity; cyclin-dependent protein kinase regulator activity; enzyme binding; histone deacetylase binding; kinase activity; protein binding; protein complex binding; protein kinase activity; protein kinase binding; transcription corepressor activity; transcription factor binding
Biological Process: fat cell differentiation; G1 DNA damage checkpoint; G1/S transition of mitotic cell cycle; lactation; Leydig cell differentiation; mammary gland epithelial cell proliferation; negative regulation of epithelial cell differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of Wnt receptor signaling pathway; positive regulation of cell proliferation; positive regulation of cyclin-dependent protein kinase activity; positive regulation of mammary gland epithelial cell proliferation; positive regulation of protein amino acid phosphorylation; protein amino acid phosphorylation; re-entry into mitotic cell cycle; regulation of cell cycle; response to DNA damage stimulus; response to organic nitrogen; unfolded protein response; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin
Reference #:  P25322 (UniProtKB)
Alt. Names/Synonyms: AI327039; bcl-1; Ccnd1; cD1; CycD1; cyclin D1; Cyl-1; G1/S-specific cyclin-D1; OTTMUSP00000031858; PRAD1
Gene Symbols: Ccnd1
Molecular weight: 33,429 Da
Basal Isoelectric point: 5.04  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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