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ATG7 Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3. Homodimer. Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5. Widely expressed, especially in kidney, liver, lymph nodes and bone marrow. Belongs to the ATG7 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 3p25.3
Cellular Component: axoneme; cytoplasm; cytosol; extracellular region
Molecular Function: APG12 activating enzyme activity; APG8 activating enzyme activity; protein binding; protein homodimerization activity; transcription factor binding; ubiquitin activating enzyme activity
Biological Process: autophagic vacuole formation; autophagy; C-terminal protein lipidation; cellular response to nitrogen starvation; cellular response to starvation; defense response to virus; macroautophagy; mitochondrion degradation; neutrophil degranulation; positive regulation of apoptosis; positive regulation of autophagy; positive regulation of protein catabolic process; positive regulation of protein modification process; protein amino acid lipidation; protein modification process
Reference #:  O95352 (UniProtKB)
Alt. Names/Synonyms: APG7 autophagy 7-like; APG7-like; APG7L; ATG7; ATG7 autophagy related 7 homolog (S. cerevisiae); Autophagy-related protein 7; DKFZp434N0735; GSA7; hAGP7; ubiquitin activating enzyme E1-like protein; Ubiquitin-activating enzyme E1-like protein
Gene Symbols: ATG7
Molecular weight: 77,960 Da
Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states
CST Pathways:  Autophagy Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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