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CREB a transcription factor of the leucine zipper family of DNA binding proteins. Binds as a homodimer to the cAMP-responsive element (CRE). Phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 1 C2|1 32.74 cM
Cellular Component: axon; chromatin; mitochondrial matrix; mitochondrion; nuclear chromatin; nucleoplasm; nucleus; transcription factor complex
Molecular Function: DNA binding; double-stranded DNA binding; enzyme binding; histone acetyltransferase binding; Hsp70 protein binding; identical protein binding; protein binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding
Biological Process: axonogenesis; circadian rhythm; lactation; mammary gland development; memory; pituitary gland development; positive regulation of apoptosis; positive regulation of cardiac muscle development; positive regulation of fat cell differentiation; positive regulation of hormone secretion; positive regulation of lipid biosynthetic process; positive regulation of multicellular organism growth; positive regulation of osteoclast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcriptional preinitiation complex assembly; positive regulation of transforming growth factor-beta3 production; protein amino acid phosphorylation; protein stabilization; regulation of apoptosis; regulation of cell size; regulation of circadian rhythm; regulation of fibroblast proliferation; regulation of transcription, DNA-dependent; response to drug; response to glucagon stimulus; response to organic substance; secretory granule organization and biogenesis; transcription from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway; visual learning
Reference #:  Q01147 (UniProtKB)
Alt. Names/Synonyms: 2310001E10Rik; 3526402H21Rik; AV083133; cAMP responsive element binding protein 1; cAMP-responsive element-binding protein 1; Creb; CREB-1; Creb1; Cyclic AMP-responsive element-binding protein 1
Gene Symbols: Creb1
Molecular weight: 36,674 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Parkinson's Disease  |  Regulation of P38 MAPKs  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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