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Bcl-11B Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 14q32.2
Cellular Component: nucleus
Molecular Function: protein binding; sequence-specific DNA binding
Biological Process: neurogenesis; positive regulation of transcription from RNA polymerase II promoter; signal transduction
Disease: Immunodeficiency 49
Reference #:  Q9C0K0 (UniProtKB)
Alt. Names/Synonyms: B-cell CLL/lymphoma 11B; B-cell CLL/lymphoma 11B (zinc finger protein); B-cell CLL/lymphoma 11B/T-cell receptor delta constant region fusion protein; B-cell lymphoma/leukaemia 11B; B-cell lymphoma/leukemia 11B; BC11B; BCL-11B; BCL11B; BCL11B/TRDC fusion; COUP-TF-interacting protein 2; CTIP-2; CTIP2; hRit1; hRIT1-alpha; Radiation-induced tumor suppressor gene 1 protein; RIT1; zinc finger protein hRit1 alpha
Gene Symbols: BCL11B
Molecular weight: 95,519 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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