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Cofilin-1 a cytoskeletal protein that controls actin depolymerization. Has a 5-10-fold higher affinity for ATP-actin monomers than cofilin-1. May promote filament assembly rather than disassembly. Two alternatively spliced variants are described. Isoform b is expressed predominantly in skeletal muscle and heart, while isoform a is expressed in various tissues. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 19|19 A
Cellular Component: cell soma; cortical actin cytoskeleton; cytoplasm; dendritic spine; extracellular matrix; extracellular space; filopodium; focal adhesion; growth cone; intercellular junction; lamellipodium; leading edge; membrane; mitochondrial membrane; neuron projection; vesicle
Molecular Function: actin binding; actin filament binding; protein phosphatase binding
Biological Process: actin filament depolymerization; actin filament fragmentation; actin filament organization; cell motility; cell projection organization and biogenesis; cytokinesis after mitosis; cytoskeleton organization and biogenesis; establishment of cell polarity; negative regulation of actin filament bundle formation; negative regulation of actin filament depolymerization; negative regulation of cell adhesion; negative regulation of cell size; negative regulation of unidimensional cell growth; neural crest cell migration; neural fold formation; positive regulation of actin filament depolymerization; positive regulation of cell growth; positive regulation of focal adhesion formation; positive regulation of proteolysis; positive regulation of synaptic plasticity; protein amino acid phosphorylation; protein import into nucleus; regulation of cell morphogenesis; response to amino acid stimulus
Reference #:  P18760 (UniProtKB)
Alt. Names/Synonyms: AA959946; Cfl1; Cof; COF1; cofilin 1, non-muscle; Cofilin, non-muscle isoform; Cofilin-1
Gene Symbols: Cfl1
Molecular weight: 18,560 Da
Basal Isoelectric point: 8.22  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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