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VAMP8 Involved in the targeting and/or fusion of transport vesicles to their target membrane. Involved for dense-granule secretion in platelets. Plays a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. Belongs to the synaptobrevin family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Vesicle
Chromosomal Location of Human Ortholog: 2p11.2
Cellular Component: clathrin coated vesicle membrane; cytoplasm; cytosol; early endosome; late endosome membrane; lysosomal membrane; membrane; perinuclear region of cytoplasm; phagocytic vesicle membrane; plasma membrane; recycling endosome; recycling endosome membrane; secretory granule membrane; SNARE complex; synaptic vesicle; vesicle
Molecular Function: chloride channel inhibitor activity; protein binding; SNAP receptor activity; SNARE binding
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; autophagic vacuole docking; entry of virus into host cell; eosinophil degranulation; neutrophil degranulation; post-Golgi vesicle-mediated transport; vesicle fusion
Reference #:  Q9BV40 (UniProtKB)
Alt. Names/Synonyms: EDB; Endobrevin; VAMP-8; VAMP8; Vesicle-associated membrane protein 8; vesicle-associated membrane protein 8 (endobrevin)
Gene Symbols: VAMP8
Molecular weight: 11,438 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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