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TH an enzyme involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Four splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tyrosine; EC; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle
Chromosomal Location of Human Ortholog: 1q41
Cellular Component: axon; cell soma; cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; cytosol; dendrite; internal side of plasma membrane; melanosome membrane; mitochondrion; neuron projection; nucleus; perikaryon; smooth endoplasmic reticulum; synaptic vesicle; terminal button
Molecular Function: amino acid binding; dopamine binding; enzyme binding; ferric iron binding; ferrous iron binding; monooxygenase activity; oxygen binding; protein binding; protein domain specific binding; tyrosine 3-monooxygenase activity
Biological Process: catecholamine biosynthetic process; cerebral cortex development; circadian sleep/wake cycle; cognition; dopamine biosynthetic process; dopamine biosynthetic process from tyrosine; eating behavior; embryonic camera-type eye morphogenesis; epinephrine biosynthetic process; eye photoreceptor cell development; fatty acid metabolic process; glycoside metabolic process; heart development; isoquinoline alkaloid metabolic process; learning; locomotory behavior; mating behavior; memory; multicellular organismal aging; norepinephrine biosynthetic process; organ morphogenesis; phthalate metabolic process; phytoalexin metabolic process; protein homotetramerization; regulation of heart contraction; response to activity; response to amphetamine; response to corticosterone stimulus; response to drug; response to electrical stimulus; response to estradiol stimulus; response to ethanol; response to ether; response to herbicide; response to hypoxia; response to insecticide; response to light stimulus; response to lipopolysaccharide; response to metal ion; response to nicotine; response to nutrient levels; response to organic cyclic substance; response to peptide hormone stimulus; response to pyrethroid; response to salt stress; response to steroid hormone stimulus; response to water deprivation; response to zinc ion; sensory perception of sound; social behavior; sphingolipid metabolic process; synaptic transmission, dopaminergic; synaptic vesicle amine transport; terpene metabolic process; visual perception
Reference #:  P04177 (UniProtKB)
Alt. Names/Synonyms: TH; The; TY3H; Tyrosine 3-hydroxylase; Tyrosine 3-monooxygenase; tyrosine hydroxylase
Gene Symbols: Th
Molecular weight: 55,966 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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