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IL-28B Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the IL-28/IL-29 family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: extracellular region; extracellular space
Molecular Function: receptor binding
Biological Process: defense response to virus; innate immune response; negative regulation of viral genome replication; regulation of T cell activation
Disease: Hepatitis C Virus, Susceptibility To
Reference #:  Q8IZI9 (UniProtKB)
Alt. Names/Synonyms: cytokine Zcyto22; IFN-lambda-3; IFN-lambda-4; IFNL3; IFNL4; IL-28B; IL-28C; IL28B; IL28C; interferon lambda-3; interferon lambda-4; interferon, lambda 3; interferon, lambda 4; interleukin 28B (interferon, lambda 3); interleukin 28C; interleukin-28B; interleukin-28C; ZCYTO22
Gene Symbols: IFNL3
Molecular weight: 21,706 Da
Basal Isoelectric point: 8.69  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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