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IL2 Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells. A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. Belongs to the IL-2 family. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Oncoprotein; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3 B|3 18.3 cM
Cellular Component: extracellular space
Molecular Function: carbohydrate binding; cytokine activity; glycosphingolipid binding; interleukin-2 receptor binding; kappa-type opioid receptor binding
Biological Process: elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; leukocyte activation during immune response; negative regulation of B cell apoptosis; negative regulation of heart contraction; negative regulation of inflammatory response; negative regulation of lymphocyte proliferation; negative regulation of protein amino acid phosphorylation; positive regulation of activated T cell proliferation; positive regulation of B cell proliferation; positive regulation of immunoglobulin secretion; positive regulation of interferon-gamma production; positive regulation of interleukin-17 production; positive regulation of isotype switching to IgG isotypes; positive regulation of protein amino acid phosphorylation; positive regulation of regulatory T cell differentiation; positive regulation of T cell differentiation; positive regulation of T cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of STAT protein; protein kinase C activation; regulation of T cell homeostatic proliferation; response to ethanol
Reference #:  P04351 (UniProtKB)
Alt. Names/Synonyms: IL-2; Il2; interleukin 2; Interleukin-2; OTTMUSP00000007837; T-cell growth factor; TCGF
Gene Symbols: Il2
Molecular weight: 19,400 Da
Basal Isoelectric point: 4.88  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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