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DLL1 Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. Interacts with Notch receptors. Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6q27
Cellular Component: adherens junction; apical plasma membrane; lipid raft; plasma membrane
Molecular Function: Notch binding; protein binding; Tat protein binding
Biological Process: astrocyte development; cell differentiation; cerebellar molecular layer formation; cerebellar Purkinje cell layer structural organization; determination of left/right symmetry; heart looping; lateral inhibition; marginal zone B cell differentiation; negative regulation of cell differentiation; negative regulation of cell proliferation; negative regulation of epidermal cell differentiation; negative regulation of epithelial cell differentiation; negative regulation of interleukin-10 production; negative regulation of myoblast differentiation; negative regulation of neuron differentiation; neuron fate specification; Notch receptor processing; Notch signaling pathway; organ growth; positive regulation of cell proliferation; positive regulation of endocytosis; positive regulation of Notch signaling pathway; positive regulation of skeletal muscle growth; positive regulation of transcription from RNA polymerase II promoter; proximal/distal pattern formation; regulation of blood pressure; regulation of cell adhesion; regulation of cell division; regulation of growth; regulation of neurogenesis; regulation of skeletal muscle growth; regulation of somitogenesis; retina development in camera-type eye; retina morphogenesis in camera-type eye; skeletal muscle growth; somitogenesis; spinal cord development
Reference #:  O00548 (UniProtKB)
Alt. Names/Synonyms: Delta; delta-like 1 (Drosophila); delta-like 1 protein; Delta-like protein 1; Delta1; DL1; DLL1; Drosophila Delta homolog 1; H-Delta-1
Gene Symbols: DLL1
Molecular weight: 78,056 Da
Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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