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CTSB Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2. Belongs to the peptidase C1 family. Note: This description may include information from UniProtKB.
Protein type: Autophagy; EC; Motility/polarity/chemotaxis; Protease
Chromosomal Location of Human Ortholog: 8p23.1
Cellular Component: extracellular region; extracellular space; intracellular; intracellular membrane-bound organelle; lysosome; nucleolus; perinuclear region of cytoplasm
Molecular Function: collagen binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity; peptidase activity; protein binding; proteoglycan binding; serine-type endopeptidase activity
Biological Process: collagen catabolic process; epithelial cell differentiation; neutrophil degranulation; proteolysis; proteolysis involved in cellular protein catabolic process; regulation of apoptosis; toll-like receptor signaling pathway
Reference #:  P07858 (UniProtKB)
Alt. Names/Synonyms: amyloid precursor protein secretase; APP secretase; APPS; CATB; Cathepsin B; Cathepsin B heavy chain; Cathepsin B light chain; Cathepsin B1; CPSB; CTSB; cysteine protease
Gene Symbols: CTSB
Molecular weight: 37,822 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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