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IL17F Stimulates the production of other cytokines such as IL- 6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6). CANDF6 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. Belongs to the IL-17 family. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 6p12.2
Cellular Component: extracellular region
Molecular Function: cytokine activity; cytokine binding; protein binding; protein homodimerization activity
Biological Process: cartilage development; cytokine biosynthetic process; lymphotoxin A biosynthetic process; negative regulation of angiogenesis; regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; regulation of interleukin-2 biosynthetic process; regulation of interleukin-6 biosynthetic process; regulation of interleukin-8 biosynthetic process; regulation of transforming growth factor beta receptor signaling pathway
Disease: Candidiasis, Familial, 6
Reference #:  Q96PD4 (UniProtKB)
Alt. Names/Synonyms: cytokine ML-1; IL-17F; IL-24; IL17F; IL24; interleukin 17F; Interleukin-17F; Interleukin-24; ML-1; ML1
Gene Symbols: IL17F
Molecular weight: 18,045 Da
Basal Isoelectric point: 9.15  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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