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IL29 Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the IL-28/IL-29 family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Cytokine; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: extracellular region; extracellular space; interleukin-28 receptor complex
Molecular Function: interleukin-28 receptor binding; receptor binding
Biological Process: defense response to virus; innate immune response; negative regulation of cell proliferation; negative regulation of interleukin-13 production; negative regulation of interleukin-5 production; negative regulation of memory T cell differentiation; negative regulation of T cell differentiation; negative regulation of T-helper 2 type immune response; negative regulation of transcription, DNA-dependent; positive regulation of immune response; positive regulation of interferon-gamma production; positive regulation of JAK-STAT cascade; positive regulation of MHC class I biosynthetic process; positive regulation of transcription, DNA-dependent; positive regulation of tyrosine phosphorylation of STAT protein
Reference #:  Q8IU54 (UniProtKB)
Alt. Names/Synonyms: cytokine Zcyto21; IFN-lambda-1; IFNL1; interferon lambda-1; interleukin-29; ZCYTO21
Gene Symbols: IFNL1
Molecular weight: 21,898 Da
Basal Isoelectric point: 9.08  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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