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CCL3 Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). Belongs to the intercrine beta (chemokine CC) family. Note: This description may include information from UniProtKB.
Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 17q12
Cellular Component: cytoplasm; cytosol; extracellular region; extracellular space; intracellular
Molecular Function: calcium-dependent protein kinase C activity; CCR1 chemokine receptor binding; CCR5 chemokine receptor binding; chemoattractant activity; chemokine activity; identical protein binding; kinase activity; phospholipase activator activity; protein binding; protein kinase activity
Biological Process: astrocyte cell migration; behavior; calcium ion transport; calcium-mediated signaling; cell activation; cell-cell signaling; cellular calcium ion homeostasis; chemotaxis; cytoskeleton organization and biogenesis; eosinophil chemotaxis; eosinophil degranulation; exocytosis; G-protein coupled receptor protein signaling pathway; inflammatory response; lipopolysaccharide-mediated signaling pathway; lymphocyte chemotaxis; macrophage chemotaxis; MAPKKK cascade; monocyte chemotaxis; negative regulation of bone mineralization; negative regulation of osteoclast differentiation; neutrophil chemotaxis; osteoblast differentiation; positive regulation of calcium ion transport; positive regulation of calcium-mediated signaling; positive regulation of cell migration; positive regulation of GTPase activity; positive regulation of inflammatory response; positive regulation of interleukin-1 beta secretion; positive regulation of neuron apoptosis; positive regulation of protein kinase B signaling cascade; positive regulation of tumor necrosis factor production; protein kinase B signaling cascade; regulation of cell shape; regulation of sensory perception of pain; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; response to toxin
Disease: Human Immunodeficiency Virus Type 1, Susceptibility To
Reference #:  P10147 (UniProtKB)
Alt. Names/Synonyms: C-C motif chemokine 3; G0/G1 switch regulatory protein 19-1; Macrophage inflammatory protein 1-alpha; MIP-1-alpha; PAT 464.1; SIS-beta; Small-inducible cytokine A3; Tonsillar lymphocyte LD78 alpha protein
Gene Symbols: CCL3
Molecular weight: 10,085 Da
Basal Isoelectric point: 4.77  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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