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LEFTY1 Required for left-right axis determination as a regulator of LEFTY2 and NODAL. Belongs to the TGF-beta family. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Ligand, receptor tyrosine kinase; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1q42.12
Cellular Component: extracellular space
Molecular Function: cytokine activity; transforming growth factor beta receptor binding
Biological Process: BMP signaling pathway; cell development; determination of left/right symmetry; heart morphogenesis; negative regulation of transcription from RNA polymerase II promoter; regulation of apoptosis; regulation of MAPKKK cascade; transforming growth factor beta receptor signaling pathway
Reference #:  O75610 (UniProtKB)
Alt. Names/Synonyms: BMP-17; BMP17; lefty b; lefty-1; lefty-b; lefty1; leftyb; stra3
Gene Symbols: LEFTY1
Molecular weight: 40,880 Da
Basal Isoelectric point: 8.6  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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