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TNFSF4 Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. Genetic variations in TNFSF4 influence susceptibility to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance. Belongs to the tumor necrosis factor family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Cytokine; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q25.1
Cellular Component: cell surface; extracellular space; integral component of plasma membrane; plasma membrane
Molecular Function: cytokine activity; receptor binding; tumor necrosis factor receptor binding; tumor necrosis factor receptor superfamily binding
Biological Process: acute inflammatory response; cholesterol metabolic process; defense response to nematode; immune response; negative regulation of cytokine secretion; negative regulation of interferon-gamma production; negative regulation of interleukin-17 production; negative regulation of regulatory T cell differentiation; negative regulation of T-helper 1 cell differentiation; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; positive regulation of activated T cell proliferation; positive regulation of alpha-beta T cell proliferation; positive regulation of B cell activation; positive regulation of CD4-positive, alpha beta T cell differentiation; positive regulation of cell proliferation; positive regulation of immunoglobulin mediated immune response; positive regulation of immunoglobulin secretion; positive regulation of inflammatory response; positive regulation of interferon-gamma production; positive regulation of interleukin-10 production; positive regulation of interleukin-12 production; positive regulation of interleukin-13 production; positive regulation of interleukin-2 production; positive regulation of interleukin-4 production; positive regulation of interleukin-6 production; positive regulation of memory T cell differentiation; positive regulation of T cell cytokine production; positive regulation of T cell proliferation; positive regulation of T-helper 2 cell differentiation; positive regulation of type 2 immune response; regulation of adaptive immune response; regulation of inflammatory response; response to virus; signal transduction; T cell proliferation; tumor necrosis factor-mediated signaling pathway
Disease: Myocardial Infarction, Susceptibility To
Reference #:  P23510 (UniProtKB)
Alt. Names/Synonyms: CD134L; CD252; GP34; OX-40L; OX4OL; TNFSF4; tumor necrosis factor (ligand) superfamily, member 4; TXGP1
Gene Symbols: TNFSF4
Molecular weight: 21,050 Da
Basal Isoelectric point: 6.95  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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