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COPS5 Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS6 and COPS7 (COPS7A or COPS7B). The CSN complex interacts with the BRISC complex. Also exists as monomeric form. Interacts with TP53, MIF, JUN, UCHL1, NCOA1, HIF1A, p27Kip1, BCL3, GFER, PGR, LHCGR, SMAD4, SMAD7, ID1, ID3, ITGB2 and TOP2A. Part of a complex consisting of RANBP9, Ran, DYRK1B and COPS5. Belongs to the peptidase M67A family. CSN5 subfamily. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; EC 3.4.-.-; Nuclear receptor co-regulator; Protease; Transcription, coactivator/corepressor; Translation
Chromosomal Location of Human Ortholog: 8q13.1
Cellular Component: cytoplasm; cytosol; eukaryotic translation initiation factor 3 complex; nucleoplasm; nucleus; signalosome; synaptic vesicle
Molecular Function: metallopeptidase activity; NEDD8-specific protease activity; protein binding; transcription coactivator activity; translation initiation factor activity; ubiquitin-specific protease activity
Biological Process: nucleotide-excision repair, DNA damage recognition; positive regulation of transcription from RNA polymerase II promoter; post-translational protein modification; protein deneddylation; protein deubiquitination; regulation of JNK cascade; transcription from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair; translation
Reference #:  Q92905 (UniProtKB)
Alt. Names/Synonyms: 38 kDa Mov34 homolog; COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis); COP9 signalosome complex subunit 5; COPS5; CSN5; JAB1; Jun activation domain-binding protein 1; MGC3149; MOV-34; SGN5; Signalosome subunit 5
Gene Symbols: COPS5
Molecular weight: 37,579 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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