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Protein Page:
eIF4G iso3

eIF4G iso3 Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with eIF3, mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1. Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA. Rapamycin can attenuate insulin stimulation mediated by FKBPs. Interacts with EIF4E3. Interacts with CIRBP and MIF4GD. Interacts with rotavirus A NSP3; in this interaction, NSP3 takes the place of PABPC1 thereby inducing shutoff of host protein synthesis. Interacts with RBM4. Belongs to the eIF4G family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Translation; Translation initiation
Chromosomal Location of Human Ortholog: 3q27.1
Cellular Component: cytoplasm; cytosol; eukaryotic translation initiation factor 4F complex; membrane; nucleus; polysome
Molecular Function: ATP binding; cadherin binding; eukaryotic initiation factor 4E binding; mRNA binding; protein binding; protein complex scaffold; RNA binding; translation factor activity, nucleic acid binding; translation initiation factor activity; translation initiation factor binding
Biological Process: developmental process; mitochondrion organization and biogenesis; mRNA catabolic process, nonsense-mediated decay; negative regulation of autophagy; poly(A) tail shortening; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of cellular protein metabolic process; positive regulation of peptidyl-serine phosphorylation; regulation of mRNA stability; regulation of translational initiation; translation; translational initiation
Disease: Parkinson Disease 18
Reference #:  Q04637-3 (UniProtKB)
Alt. Names/Synonyms: DKFZp686A1451; eIF-4-gamma 1; eIF-4G 1; eIF-4G1; EIF4-gamma; EIF4F; EIF4G; EIF4G1; EIF4GI; Eukaryotic translation initiation factor 4 gamma 1; eukaryotic translation initiation factor 4 gamma, 1; IF4G1; p220
Gene Symbols: EIF4G1
Molecular weight: 171,514 Da
Basal Isoelectric point: 5.23  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF4E and p70S6K  |  Translational Control
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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eIF4G iso3

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