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Protein Page:

CENPA a basic nuclear protein of the histone H3 family. May act as a core histone necessary for the assembly of centromeres. Contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 2p23.3
Cellular Component: chromosome, pericentric region; condensed nuclear chromosome, pericentric region; cytosol; nucleoplasm; nucleus
Molecular Function: chromatin binding; nucleosomal DNA binding; protein binding
Biological Process: cytokinesis after mitosis; DNA replication-independent nucleosome assembly at centromere; establishment of mitotic spindle orientation; kinetochore assembly; nucleosome assembly; sister chromatid cohesion
Reference #:  P49450 (UniProtKB)
Alt. Names/Synonyms: CENP-A; CENPA; Centromere autoantigen A; Centromere protein A; centromere protein A, 17kDa; Histone H3-like centromeric protein A
Gene Symbols: CENPA
Molecular weight: 15,991 Da
Basal Isoelectric point: 11.71  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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