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CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1. A cell-cell adhesion molecule that directly associates with annexin II. Has tumor suppressor activity in prostate carcinoma. Belongs to the immunoglobulin superfamily and the CEA family. Abundantly expressed in epithelia, vessel endothelia, trophoblasts, platelets and neutrophilic granulocytes. Also present in many cell types of the immune system such as B cells, T cells, NK cells, macrophages and dendritic cells. Five alternatively spliced isoforms have been described. Two isoforms are type I membrane proteins, while three are secreted. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: adherens junction; apical plasma membrane; basal plasma membrane; cell junction; cell surface; integral to membrane; intercellular junction; lateral plasma membrane; membrane; plasma membrane; T cell receptor complex
Molecular Function: actin binding; bile acid transmembrane transporter activity; filamin binding; kinase binding; protein binding; protein dimerization activity; protein homodimerization activity; protein phosphatase binding
Biological Process: bile acid and bile salt transport; blood vessel development; cell adhesion; cellular response to insulin stimulus; homophilic cell adhesion; leukocyte migration; negative regulation of cytotoxic T cell degranulation; negative regulation of fatty acid biosynthetic process; negative regulation of granulocyte differentiation; negative regulation of interleukin-1 production; negative regulation of lipid biosynthetic process; negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; negative regulation of protein kinase activity; negative regulation of T cell mediated cytotoxicity; negative regulation of T cell receptor signaling pathway; negative regulation of vascular permeability; neutrophil degranulation; regulation of cell growth; regulation of cell migration; regulation of endothelial cell differentiation; regulation of epidermal growth factor receptor signaling pathway; regulation of phosphoinositide 3-kinase cascade
Reference #:  P13688 (UniProtKB)
Alt. Names/Synonyms: antigen CD66; BGP; BGP-1; BGP1; BGPI; Biliary glycoprotein 1; biliary glycoprotein adhesion molecule; Carcinoembryonic antigen-related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); CD66a antigen; CEACAM1; CEAM1
Gene Symbols: CEACAM1
Molecular weight: 57,560 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
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