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RRAGD Has guanine nucleotide-binding activity but lacks intrinsic GTPase activity. Probably required for the amino acid- induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Forms a heterodimer with RRAGA in a sequence-independent manner. Binds GTP. Interacts with NOL8 and RRAGB. Belongs to the GTR/RAG GTP-binding protein family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: G protein regulator, misc.
Chromosomal Location of Human Ortholog: 6q15
Cellular Component: centrosome; cytoplasm; cytosol; lysosome; nucleoplasm; nucleus
Molecular Function: GDP binding; GTP binding; GTPase activity; GTPase binding; protein binding; protein heterodimerization activity
Biological Process: cell cycle arrest; regulation of autophagy; regulation of macroautophagy
Reference #:  Q9NQL2 (UniProtKB)
Alt. Names/Synonyms: bA11D8.2.1; DKFZp761H171; FLJ44176; Rag D; Rag D protein; RagD; Ras-related GTP binding D; Ras-related GTP-binding protein D; RRAGD
Gene Symbols: RRAGD
Molecular weight: 45,588 Da
Basal Isoelectric point: 4.76  Predict pI for various phosphorylation states
CST Pathways:  mTOR Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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